Biostimulators: Ellansé, HArmonyCa, AestheFill, Sculptra, Radiesse, Juvelook… What are they?

Biostimulators represent a significant advancement in aesthetic medicine, offering a non-surgical approach to skin rejuvenation. As we age, our skin’s natural collagen production diminishes, leading to wrinkles, sagging, and a loss of firmness. Biostimulators address these concerns by encouraging the body’s own collagen production, resulting in a more youthful and revitalised appearance.

What are Biostimulators?

Biostimulator treatments are minimally invasive procedures that enhance the body’s natural collagen production. Substances like Poly-L-lactic Acid (PLLA) or Calcium Hydroxyapatite (CaHA) are injected into the deep dermis to rejuvenate the skin’s structure and volume. The treatment works by stimulating fibroblasts, the cells responsible for collagen production. This process not only augments current collagen levels but also helps reduce future collagen degradation.

Biostimulator works well for persons who have sagging skin, reduced elasticity and moisture, dry and lifeless skin, wide pores, uneven skin texture, deep facial wrinkles, sagging cheeks, loose skin, and those who are suffering premature ageing and skin laxity.

Common Biostimulators in Hong Kong

1. HArmony CA

HArmonyCa serves a dual purpose as a filler and a biostimulator. HArmonyCa offers a blend of Hyaluronic Acid (HA) and Calcium Hydroxyapatite (CaHA) microspheres. The HA in HArmonyCa delivers instant volume enhancement, boosting skin hydration for a fuller, healthier complexion. Meanwhile, the CaHA microspheres trigger the body’s collagen production, leading to the growth of new collagen fibres.

This dual-action formula provides immediate and long-term benefits. It not only restores volume instantly but also continues to stimulate collagen for up to 18-24 months post-treatment.

HArmonyCa is designed for augmenting facial soft tissue through deep dermal and subdermal injections. It’s suitable for those aiming to enhance facial structure and is known for its sustained lifting effect due to new collagen production.

Recommended treatment sites for HArmonyCa: Middle and lower face, to improve nasolabial fold, marionette lines and jawline.

2. Ellansé

Ellansé is a unique type of dermal filler that is injected into the skin. It is made of polycaprolactone (PCL) microspheres, mixed with a carboxymethyl cellulose (CMC) gel carrier. The gel delivers immediate results, while the PCL microspheres act as a biostimulator, ramping up the production of your own collagen. This improves skin elasticity and creates a more youthful appearance.

Ellansé are available in S and M models, which have different benefit times. Generally, they can last for 1-2 years.

Equipped with the exclusive patented STAT™ technology, Ellansé can be filled instantly to enhance contours and improve wrinkles, facial depression and other facial problems. The active ingredient PCL in the injection activates collagen regeneration, making the longer lasting plumping and smoothing effect. Ellansé has been certified by the US FDA and the EU CE, and can be completely decomposed, absorbed and excreted by the human body, making it highly efficient and safe.

Recommended treatment sites for Ellansé: Temples, nasolabial folds, marionette lines, jawline
Suitable for: Large-area depressions

3. AestheFill

AestheFill is an innovative, cutting-edge injectable dermal filler that stimulates collagen production, reducing the appearance of fine lines, wrinkles, and sagging skin. It harnesses the power of PDLLA, poly-D, L-lactic acid (PDLLA) microspheres, restoring skin elasticity, creating a fuller and firmer appearance.

AestheFill can be used to stimulate collagen proliferation in a long-term and sustained manner over a large facial area, giving a comprehensive, plumping and lifting effect. Generally, they can last up to 1-2 years.

Recommended treatment sites for AestheFill: Forehead, tear trough, temples, cheeks, nasolabial folds, marionette lines, neck lines
Suitable for: Thinner skin sites on face, partial sculpting

4. Radiesse 美肌針

Radiesse is an innovative biostimulator that prompts collagen and elastin production, creating a new network of skin fibres for stronger, more complete skin. It contains Calcium Hydroxylapatite (CaHA) microspheres, which are instrumental in stimulating collagen and elastin production.

Radiesse can be diluted to the desired hardness, and the texture can be soft or hard. It has strong filling and shaping ability and can create sharp and full effects. In addition to being injected on the face, Radiesse can also be injected into the back of the hands. It is approved by the US FDA for use on the face and hands. Results can last for one year or more after treatment is completed.

Recommended treatment sites for Radiesse: Back of hands, temples, cheeks, nasolabial folds, marionette lines, jawline, neck lines
Suitable for: Large-area depressions, partial sculpting, thinner skin sites on face, skin conditions.

5. Sculptra童顏針

Sculptra, or poly-L-lactic acid (PLLA), stands out in injectable cosmetic treatments due to its synthetic, biocompatible, and biodegradable nature. It stimulates the body’s regenerative collagen-building processes, offering more than just superficial changes.

Sculptra contains collagen-promoting PLLA and is the world's only PLLA medical aesthetic brand approved by the US FDA. Sculptra can effectively stimulate the self-generation of collagen in the body, improve facial skin pit lines and various wrinkles, and more naturally and gradually improve sunken and sagging phenomena caused by the loss of subcutaneous tissue on the face, making your skin plump and plump. Generally, results can last for 2 years.

Recommended treatment sites for Sculptra: Temples, cheeks, nasolabial folds, marionette lines, jawline
Suitable for: Large-area depressions

6. Juvelook

Juvelook is specifically targeted at superficial skin. It is the smallest PDLLA micromolecule product on the market, so it can be injected into the dermis. After treatment, it provides immediate fine filling and moisturising effects, it can continue to stimulate the proliferation of collagen and elastin.

It mainly improves the skin's moisture retention, especially for eliminating pores, uneven holes, scars, smoothing fine lines on the face and rejuvenating the skin. It comprehensively improves skin quality and restores plumpness and firmness. It can also be used for neck lines, stretch marks. Results normally last for 6-12 months.

Recommended treatment sites for Juvelook: fine lines, eliminating pores, uneven holes, scars, stretch marks, neck lines
Suitable for: Overall skin conditions, thinner skin sites on face, pores and fine lines

Each of these biostimulators has unique properties and benefits. The choice between them depends on the individual’s specific needs, desired results, and consultation with a qualified medical professional. It’s always recommended to consult with a doctor to understand which treatment is most suitable for you.

Benefits of Biostimulators

The benefits of collagen biostimulators are rooted in their ability to enhance the skin’s natural regenerative capabilities. Key advantages include:

Enhancement of Skin Elasticity: By boosting collagen production, these treatments improve the skin’s elasticity, helping to reduce the appearance of sagging and wrinkles.
Improvement in Skin Texture: Patients often observe a more even skin texture, with a noticeable reduction in the appearance of fine lines and pores.
Restoration of Facial Volume: Collagen biostimulators can help replenish lost facial volume in a natural-looking way, counteracting the hollow or sunken appearance often associated with ageing.
Long-Lasting Results: The effects of collagen biostimulators are not immediate but develop over time, offering long-lasting improvements in skin quality.
Preventative Anti-Ageing Effects: These treatments can also be used proactively to slow down the ageing process, helping to maintain a youthful complexion.
Minimal Downtime: Typically, these procedures involve minimal downtime, allowing patients to return to their daily activities shortly after treatment.

Conclusion

Biostimulators, including options like Ellansé, HArmonyCa, AestheFill, Sculptra, Radiesse, Juvelook, provide a method for skin rejuvenation, tailored to various individual needs. A consultation with a qualified medical professional is essential to determine the appropriateness and expected outcomes of the treatment. Biostimulators represent a promising future in aesthetic medicine, offering a non-surgical, effective, and long-lasting solution to skin ageing.

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